Writing in the autobiography, the Nobel laureate Franзois Jacob described the way the means of science was actually quite different from that which was eventually written and published when you look at the peer-reviewed literature. 1 He related how Sydney Brenner to his research and Matthew Meselsen initially had setbacks once they tried to identify a hypothesized intermediary molecule that took information from genes and allowed protein to be synthesized inside cells. He and his colleagues attempted, without luck, to show that the factor, which we know as mRNA, attached itself to ribosomes, the cell’s protein-manufacturing machinery today. So one day, discouraged, Jacob said, he and Brenner took a rest and went to a Pacific Ocean beach, where Brenner at some point exclaimed that magnesium was important for binding.
If the two gone back to the laboratory, they added enough magnesium to their experiments and then showed the factor connected with ribosomes. Read More